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How One Change to The Coronavirus Spike Influences Infectivity


18 Jan 2022

Since joining NIH, I’ve held a number of different leadership positions. But there is one position that thankfully has remained constant for me: lab chief. I run my own research laboratory at NIH’s National Institute of Dental and Craniofacial Research (NIDCR). My lab studies a biochemical process called O-glycosylation. It’s fundamental to life and fascinating to study. Our cells are often adorned with a variety of carbohydrate sugars. O-glycosylation refers to the biochemical process through which these sugar molecules, either found at the cell surface or secreted, get added to proteins. The presence or absence of these sugars on certain proteins plays fundamental roles in normal tissue development and first-line human immunity. It also is associated with various diseases, including cancer.


Shipments of free coronavirus tests will take at least a week, U.S. officials say


14 Jan 2022

Americans will be able to order free rapid coronavirus tests online at COVIDTests.gov beginning on Wednesday, but the tests will take time to arrive: they will typically ship within 7 to 12 days after being ordered, senior Biden administration officials said on Friday.


Starting later this week, some at-risk Americans become eligible for a 4th shot.


13 Jan 2022

Some people with a weakened immune system can get a fourth dose of the coronavirus vaccine as early as this coming week, according to recommendations from the Centers for Disease Control and Prevention that were updated last week. The C.D.C. endorsed a third dose of the Pfizer-BioNTech and Moderna vaccines for moderately or severely immunocompromised people on Aug. 13, but said this would be considered a part of the primary immunization, not a booster shot.


Is It Flu, COVID-19, Allergies, or a Cold?


12 Jan 2022

Feeling sick can be especially concerning these days. Could your sniffles be caused by COVID-19? Or the flu? A cold? Or maybe allergies? Determining the cause of an illness can be tricky because many share some symptoms. They can leave you sniffling, coughing, and feeling tired. But there are important differences.


Biomedical Research Leads Science’s 2021 Breakthroughs


04 Jan 2022

Breakthrough of the Year: AI-Powered Predictions of Protein Structure The biochemist Christian Anfinsen, who had a distinguished career at NIH, shared the 1972 Nobel Prize in Chemistry, for work suggesting that the biochemical interactions among the amino acid building blocks of proteins were responsible for pulling them into the final shapes that are essential to their functions. In his Nobel acceptance speech, Anfinsen also made a bold prediction: one day it would be possible to determine the three-dimensional structure of any protein based on its amino acid sequence alone. Now, with advances in applying artificial intelligence to solve biological problems—Anfinsen’s bold prediction has been realized.




Articles


Sorting Out Whether Vitamin D Deficiency Raises COVID-19 Risk


06 Jan 2021

One of the risk factors du jour for coronavirus disease 2019 (COVID- 19) has been vitamin D deficiency.




Emergence of a Highly Fit SARS-CoV-2 Variant


31 Dec 2020

Sarbecoviruses have emerged twice in the 21st century, causing a worldwide epidemic and pandemic.




U.S. Officials Say Covid-19 Vaccination Effort Has Lagged


30 Dec 2020

The distribution of vaccines in the United States has gotten off to a slower-than-expected start, federal health officials acknowledged in a news conference on Wednesday, though they also voiced confidence that the pace would accelerate in the coming weeks.




Coronavirus Vaccine Tracker


30 Dec 2020

Vaccines typically require years of research and testing before reaching the clinic, but in 2020, scientists embarked on a race to produce safe and effective coronavirus vaccines in record time. Researchers are currently testing 64 vaccines in clinical trials on humans, and 19 have reached the final stages of testing. At least 85 preclinical vaccines are under active investigation in animals.




Help Fight Medicare Fraud


30 Dec 2020

Medicare covers the COVID-19 vaccine at no cost to you, so if anyone asks you to share your Medicare Number or pay for access to the vaccine, you can bet it’s a scam.




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