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Delivering Extra Protection Against COVID-19


27 Jul 2023

What you need to know SARS-CoV-2, the virus that causes COVID-19, is covered in spike proteins. These spike proteins interact with a protein called angiotensin-converting enzyme 2 (ACE2) that sits on the surface of human cells. By attaching to ACE2, the virus can infect the human cells. Because ACE2 does not change, the part of the spike protein that interacts with ACE2 is unlikely to change or mutate. This makes the development of “decoy” ACE2 proteins — proteins that bind to SARS-CoV-2 before it can attach to human cells — a promising target for new treatments.


What Long COVID Looks Like in Children and Young Adults


22 May 2023

At least 15 million kids have been infected with SARS-CoV-2, the virus that causes COVID-19, but it is unclear how many of them have had or are living with long COVID. The ailment includes symptoms that linger after COVID-19 or symptoms that come back after an absence of weeks or months. A person might feel short of breath, lose their sense of smell, be unable to think clearly, be tired all the time, or have other maladies that can be traced back to COVID-19.


Rapid Progression of Dementia Following COVID-19


03 May 2023

What you need to know COVID-19 can cause long-term problems with thinking, concentrating, and remembering. This condition is commonly known as “brain fog.” Brain fog after COVID-19 has been studied mostly by observing previously healthy people. In a small study supported by the National Institute of Neurological Disorders and Stroke (NINDS), researchers examined the cognitive impact of COVID-19 on people with dementia. The researchers found that having COVID-19 rapidly accelerated the structural and functional brain deterioration of patients with dementia, regardless of the type of dementia being experienced.


Symptoms of Long COVID Differ for People of Different Racial and Ethnic Groups


06 Apr 2023

What you need to know As the COVID-19 pandemic continues, a growing number of people are experiencing long-term symptoms and health problems following SARS-CoV-2 infection, a condition known as Long COVID. However, the likelihood of being diagnosed with Long COVID seems to vary. A study supported by the Researching COVID to Enhance Recovery (RECOVER) Initiative found that the majority of patients from a sample of more than 30,000 patients with a Long COVID diagnosis were White, non-Hispanic, female, and likely to live in more affluent areas with greater access to health care. Because the COVID-19 pandemic has disproportionately affected people from racial and ethnic minorities, this finding may mean that people from those groups are living with Long COVID without a formal diagnosis.


Antiviral Treatment Reduces Likelihood of Severe Illness From Omicron


09 Feb 2023

hat you need to know Antiviral drugs can lower the risk of severe illness and death from viral infections. In 2021, a clinical trial showed that Paxlovid — an antiviral treatment known generically as nirmatrelvir and ritonavir — reduces the risk of severe COVID-19. Since then, the antiviral treatment has been administered more than 7.6 million times and is available by prescription at more than 40,000 locations in the United States. The study that showed the effectiveness of Paxlovid occurred when the Delta variant was the dominant strain of SARS-CoV-2, the virus that causes COVID-19. In a new study supported by the National Institute of Allergy and Infectious Diseases and the National Cancer Institute, researchers have found that the drug still reduces risk of hospitalization and death from the Omicron variant of SARS-CoV-2.




Articles


Randomized Trial of a Third Dose of mRNA-1273 Vaccine in Transplant Recipients


11 Aug 2021

In organ-transplant recipients, the standard two-dose vaccination strategy for coronavirus disease 2019 (Covid-19) has suboptimal immunogenicity.1 Both patients and health care providers have questioned whether a third-dose booster in transplant recipients would be safe and enhance immune response.2 We performed a double-blind, randomized, controlled trial of a third dose of mRNA-1273 vaccine (Moderna) as compared with placebo (the protocol is available with the full text of this letter at NEJM.org; ClinicalTrials.gov number, NCT04885907. opens in new tab).




Long-term Symptoms After SARS-CoV-2 Infection in Children and Adolescents


15 Jul 2021

Children can experience SARS-CoV-2 postviral syndromes, but it is unclear to what extent these individuals are affected by long COVID. Evidence is predominantly limited to select populations without control groups,1-4 which does not allow estimating the overall prevalence and burden in a general pediatric population. We compared symptoms compatible with long COVID in children and adolescents (hereafter “children”) reported within 6 months after SARS-CoV-2 serologic testing.




Study Suggests Lasting Immunity After COVID-19, With a Big Boost From Vaccination


14 Jul 2021

After an infection with SARS-CoV-2, most people—even those with mild infections—appear to have some protection against the virus for at least a year, a recent follow-up study of recovered patients published in Nature suggests. What’s more, this and other research demonstrates that vaccinating these individuals substantially enhances their immune response and confers strong resistance against variants of concern, including the B.1.617.2 (delta) variant.




Return to Play After COVID-19 Infection in Children


28 Jun 2021

As the pandemic continues, children may experience long-term effects from COVID-19 infections. Because children may become “long haulers” or develop multisystem inflammatory syndrome in children (MIS-C), close monitoring after a COVID-19 diagnosis is important. In addition, children who are athletes require a separate return-to-play evaluation before they return to competitive sports or physical activities.




Association of Mask Mandates and COVID-19 Case Rates, Hospitalizations, and Deaths in Kansas


23 Jun 2021

This study examined the association between mask mandates in Kansas counties and COVID-19 cases, hospitalizations, and deaths. The Kansas executive order that took effect on July 3 was adopted by only 15 counties, and 68 counties did not have a mandate through October. A second mask mandate order took effect on November 25, and 40 additional counties adopted it.




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