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Severe COVID-19 May Cause Long-Term Immune System Changes


30 Nov 2023

What you need to know In a small study supported by the National Institute of Allergy and Infectious Diseases (NIAID), severe cases of COVID-19 were shown to cause long-lasting changes to the immune system. Researchers found that severe cases of COVID-19 can change which genes are turned on or off in certain stem cells. The study focused on stem cells that produce white blood cells, a part of the immune system. The stem cells of people who recovered from severe COVID-19 produced more white blood cells — which then produced more inflammatory signals — than the cells of healthy counterparts.


Severe COVID-19 May Cause Long-Term Immune System Changes


30 Nov 2023

What you need to know: In a small study supported by the National Institute of Allergy and Infectious Diseases (NIAID), severe cases of COVID-19 were shown to cause long-lasting changes to the immune system. Researchers found that severe cases of COVID-19 can change which genes are turned on or off in certain stem cells. The study focused on stem cells that produce white blood cells, a part of the immune system. The stem cells of people who recovered from severe COVID-19 produced more white blood cells — which then produced more inflammatory signals — than the cells of healthy counterparts.


SARS-CoV-2 infects coronary arteries, increases plaque inflammation


28 Sep 2023

NIH-funded research sheds light on the link between COVID-19 infection and increased risk of cardiovascular disease and stroke SARS-CoV-2, the virus that causes COVID-19, can directly infect the arteries of the heart and cause the fatty plaque inside arteries to become highly inflamed, increasing the risk of heart attack and stroke, according to a study funded by the National Institutes of Health. The findingsexternal link, published in the journal Nature Cardiovascular Research, may help explain why certain people who get COVID-19 have a greater chance of developing cardiovascular disease, or if they already have it, generate more heart-related complications.


Cold virus may set the stage for Long COVID


20 Sep 2023

At a Glance Prior infection with a common cold coronavirus may predispose some people to develop Long COVID. The findings identify a potential marker that could help identify people at high risk of developing Long COVID.


Genetic variant associated with absence of COVID-19 symptoms


09 Aug 2023

At least 20% of people infected with SARS-CoV-2, the virus that causes COVID-19, never showed symptoms. These asymptomatic infections could provide clues to how the virus can be quickly cleared from the body. Genetic factors may be involved. However, most studies of genetics and COVID-19 outcomes to date have focused on severe disease.




Articles


SARS-CoV-2 Vaccines


26 Feb 2021

Shortly after SARS-CoV emerged at the turn of the 21st century, the spike (S) protein (particularly in its prefusion [native] conformation) was identified as the immunodominant antigen of the virus. Evaluation of patients with SARS-CoV-2 revealed that binding and neutralizing antibodies primarily target the receptor-binding domain of the S1 subunit.




SARS-CoV-2 Variants of Concern in the United States—Challenges and Opportunities


17 Feb 2021

. SARS-CoV-2, like other RNA viruses, constantly changes through mutation, with new variants occurring over time. Generally, when new variants become more common, they do so because of some selective advantage to the virus.




The US Regulatory System and COVID-19 Vaccines The Importance of a Strong and Capable FDA


15 Feb 2021

For many in public health and medicine, the coronavirus disease 2019 (COVID-19) pandemic in the US has been a frustrating journey from one disappointment to the next: late access to testing, insufficient staff and inadequate funding for contact tracing, jumbled communications, and, at the end of 2020, a chaotic launch of vaccination efforts.




COVID-19 Vaccination in Pregnant and Lactating Women


08 Feb 2021

Pregnant women with severe or critical coronavirus disease 2019 (COVID-19) infection are at increased risk for preterm birth and pregnancy loss.




Durability of Responses after SARS-CoV-2 mRNA-1273 Vaccination


04 Feb 2021

We recently reported the results of a phase 1 trial of a messenger RNA vaccine, mRNA-1273, to prevent infection with SARS-CoV-2; those interim results covered a period of 57 days after the first vaccination.




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